Prevention and home treatments for cold sores—and what makes some of us prone to get them while other people never do. The herpes virus, an ancient and unwelcome human companion, comes in more than one form. Herpes simplex 1 is almost always the culprit in cold sores or fever blisters that erupt around the mouth; herpes simplex 2 is generally responsible for genital herpes. Cold sores are no fun. Learn about Valtrex, a prescription drug that could help you shorten the time you have cold sores or even avoid them altogether. There are several medications to reduce the duration of symptoms of cold sores. Some are available without a prescription (over the counter), and others require a prescription from a doctor. Cold sores are often known as fever blisters given their appearance. Most cold sores are caused by HSV-1, also known as Herpes Simplex Virus. According to the World Health Organization, around two. I’m not only outbreak free, I’m now stress free I’m 34 years old and found out in 2005 that I have herpes. I can’t speak for others, but after using every topical cream and ointment on the planet, I concluded ProsurX is definitely 100x better. Cold sores are little, unsightly and often painful blisters that happen most frequently on the lips and adjacent skin, though occasionally on gums or the nose. This page provides comprehensive information about the canker sore and cold sore remedies. Before you go! Sign up for the FREE weekly email newsletter from the publishers of American Nurse Today. You’ll get breaking news features, exclusive investigative stories, and more — delivered to your inbox. Unfortunately, I suffer from cold sores from time to time. They are embarrassing and you just want them to go away as soon as possible. Abreva tends to be fairly expensive for even a very little amount, but it is a potent medication. Cold Sore Prescription Medication 1: Valtrex. Valtrex is one of the top prescription medications for cold sores. Valtrex is the brand name for valacyclovir, an antiviral drug that is most commonly used to treat infections by the herpes viruses that cause cold sores, genital herpes, and shingles.